BDBM50310786 CHEMBL1078220::guttiferone P

SMILES: [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6][C@]12[#6]-[#6@@H](-[#6]\[#6]=[#6](\[#6])-[#6])[C@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6]1=O)[#6]2=O

InChI Key: InChIKey=VXBWNOKLYLOZDB-VGHCTATHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50310786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50310786 (CHEMBL1078220 | guttiferone P) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6][C@]12[#6]-[#6@@H](-[#6]\[#6]=[#6](\[#6])-[#6])[C@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6]1=O)[#6]2=O |r,TLB:48:47:34.45.32:18.11.12| Show InChI InChI=1S/C43H58O6/c1-27(2)13-11-15-31(9)21-23-42-26-33(18-16-29(5)6)41(10,22-12-14-28(3)4)43(40(42)49,24-20-30(7)8)39(48)36(38(42)47)37(46)32-17-19-34(44)35(45)25-32/h13-14,16-17,19-21,25,33,36,44-45H,11-12,15,18,22-24,26H2,1-10H3/b31-21+/t33-,36?,41+,42+,43-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Griffith University Curated by ChEMBL					Assay Description Inhibition of GST-tagged MAPKAPK2 assessed as [33P] incorporation after 40 mins by scintillation proximity assay				J Nat Prod 72: 1699-701 (2009) Article DOI: 10.1021/np900246t BindingDB Entry DOI: 10.7270/Q2X0675D
					More data for this Ligand-Target Pair